Regulome analysis
miRNA, siRNA, tnRNA and ChIP analysis
Small RNAs are short molecules with 21–28 nucleotides. They are present in eukaryotic cells in addition to RNA with functions as miRNA, siRNA, tnRNA and fulfill important functions in the regulation of cellular processes such as growth regulation, differentiation, apoptosis, development of cancer and neurogenesis. Despite having the same origin and function, they are often given different names and are subdivided into different classes, e.g. miRNAs (micro RNAs), siRNAs (short interfering RNAs), tnRNAs (tiny non-coding RNAs)
Chromatin immunoprecipitation (ChIP) is an in vivo method of identifying the bonding sites of proteins to a DNA sequence. The knowledge about such DNA-protein interactions is important for the understanding of many biological processes and various diseases. Whereas the established method of ChIP analysis using microarrays is limited to a certain number of samples, the sequencing with Next Generation technologies can characterize the DNA-protein interactions of a complete genome in one single run.
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