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Integrated phenotype/genotype platform (IPG): Further progress in biotechnological strain development by identifying unknown metabolic engineering targets


The IPG project aims to identify mutations and their combination patterns as are required for an industrially relevant high-producing phenotype. High-throughput platforms with maximum automation are used to conduct phenotyping and genotyping of mutagenized L-lysine producing C. glutamicum. One of the project’s main goals is to further develop the experimental IPG platform and the specialized data analysis software on which it is based. The necessary genetic diversity of the strains to be produced and analysed during the project will be created by means of mutagenesis and selection.

GATC Biotech’s task:

The genomes of selected strains will be analysed using latest generation sequencing technologies. Furthermore, we will develop new standard protocols for sample preparation and subsequent processing of raw data. The protocols will be seamlessly integrated into the IPG platform described above. The work will include the definition and implementation of a technology-independent quality evaluation process for genomic sequencing data and SNPs as well as the development and preparation of new assembly strategies.

Participating partners:

Bielefeld University, Bielefeld, Germany

Evonik Degussa GmbH, Halle/Westfalen, Germany

Genedata Bioinformatik GmbH, Planegg, Germany

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